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Stay tuned, this page is not fully complete, please help keep it complete by adding up to 2 relevant movies details below.A cardioprotective role of the cardiac adenine nucleotide translocase in mouse heart.
Cardiac adenine nucleotide translocase (ANT) is present in intercalated discs, the region where the intercellular electrical syncytium is located. This localization suggests that ANT may be involved in cellular signalling, transport, and/or exchange of adenine nucleotides. To test whether ANT is functionally related to signal transduction and/or cardiac ion transport, cardiomyocyte-specific ANT knockout mice (ANT(cko)) were developed and characterized. Female ANT(cko) mice were healthy and exhibited no obvious heart dysfunction. ANT(cko) mice had an accumulation of ATP within mitochondria and a low, but detectable, level of the ANT inhibitor ADP, supporting the idea that ANT is functionally important. Despite normal ATP concentrations in cardiac tissue and normal cardiac pump function, an increase in the expression of ATP-sensitive potassium (K(ATP)) channel alpha-subunits was found in the ventricle of ANT(cko) mice. This increase was associated with a trend toward reduced electrical excitability in ventricular cardiomyocytes. We conclude that ANT activity in the cardiomyocyte is not essential for normal heart function, but the absence of this enzyme results in a compensatory up-regulation of ATP-sensitive K(+) channels.It seems to me that a lot of great bluegrass music can be described as rolling thunder. Maybe that makes some aspects of the music sound dull, but I’d argue that a lot of folk music, blues, rock, and jazz can be described as rolling thunder, and these genres can be equally great. The same applies to the music of Evanescence, as seen from some of their early work to their most recent, and my belief is that they have a place on this list as well.
6. “Broken” (fall 2005)
Way to go, Evanescence. After a few forgettable albums, you picked yourself
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